Renal Scarring in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Trial
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چکیده
منابع مشابه
Renal Scarring in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Trial.
BACKGROUND AND OBJECTIVES The main objectives of the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial were to evaluate the role of antimicrobial prophylaxis in the prevention of recurrent urinary tract infection (UTI) and renal scarring in children with vesicoureteral reflux (VUR). We present a comprehensive evaluation of renal scarring outcomes in RIVUR trial parti...
متن کاملRandomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators.
Because of the frequency of urinary tract infections in children, off-label use of antimicrobial prophylaxis is often the usual treatment of children with vesicoureteral reflux, and such use is increasingly being called into question; hence, a definitive study to determine the value of antimicrobial prophylaxis with regard to the recurrence of urinary tract infection and the incidence of renal ...
متن کاملRationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study.
OBJECTIVE Our goal is to determine if antimicrobial prophylaxis with trimethoprim/sulfamethoxazole prevents recurrent urinary tract infections and renal scarring in children who are found to have vesicoureteral reflux after a first or second urinary tract infection. DESIGN, PARTICIPANTS, AND METHODS The Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study is a double-...
متن کاملThe RIVUR trial: profile and baseline clinical associations of children with vesicoureteral reflux.
BACKGROUND AND OBJECTIVE Vesicoureteral reflux (VUR) is diagnosed in ∼30% to 40% of children who have imaging studies after urinary tract infections (UTIs). Our goal is to characterize children enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial and to compare our study cohort with those from previously published studies. METHODS RIVUR investigators f...
متن کاملRenal scarring and osteopontin gene C/T polymorphism in children with primary vesicoureteral reflux.
We examined for osteopontin (OPN) gene C/T polymorphism in 78 patients (53 girls) with vesicoureteric reflux, with or without renal scarring. The T allele frequency was associated with a significantly increased risk (26.4 fold) of renal scarring.
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2015
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.05210515